Pax7 is back

Pax7 Is Required for the Specification of Myogenic Satellite Cells

The paired box transcription factor Pax7 was isolated by representational difference analysis as a gene specifically expressed in cultured satellite cell-derived myoblasts. In situ hybridization revealed that Pax7 was also expressed in satellite cells residing in adult muscle. Cell culture and electron microscopic analysis revealed a complete absence of satellite cells in Pax7(-/-) skeletal mus...

Pax7-FKHR transcriptional activity is enhanced by transcriptionally repressed MyoD.

Alveolar rhabdomyosarcoma (ARMS) are characterized by the expression of chimeric transcription factors Pax3-FKHR and Pax7-FKHR, due to chromosomal translocations fusing PAX3 or PAX7 with the FKHR gene. Although ARMS exhibits a muscle lineage phenotype, the cells evade terminal differentiation despite expressing the potent myogenic transcriptional regulator MyoD. Here we show that while Pax7-FKH...

Behaviourism Is Back !

It was not long ago that behaviourism was almost a contemptuous epithet, if not a contretemps career epitaph, and few theorists wished to be mistaken for behaviourists. However, there has been a recent shift of alliances with the emergence of a new breed of researchers that openly advocate the incorporation of behaviourism into the study of consciousness. This critical essay is therefore devote...

Wilbur is back.

Metadata is back!

1. TALK SUMMARY I chose the title Metadata is back! because of schema.org, which is a joint effort of Bing, Google and Yahoo to provide a collection of schemas for marking up Web pages with machine-readable data. This helps search engines to understand the meaning of information and allows them to provide rich search results to the user, which makes it easier for them to find relevant informati...